First Warm, Then Wet

First remodel, then recycle

M ultivesicular bodies (MVBs) are specialized endosomes that promote the degradation of membrane proteins by delivering them to lysosomes. This process is regulated by a series of endosomal sorting complexes required for transport (ESCRTs) (1). The ESCRT-0,-I, and-II complexes sequester ubiquitinated membrane proteins and recruit the ESCRT-III complex to drive the invagination and release of ca...

First Them, Then Us

First depressed, then discriminated against?

Each year a substantial share of the European population suffers from major depression. This mental illness may affect individuals' later life outcomes indirectly by the stigma it inflicts. The present study assesses hiring discrimination based on disclosed depression. To this end, between May 2015 and July 2015, we sent out 288 trios of job applications from fictitious candidates to real vacan...

The case for rainfall on a warm, wet early Mars

[1] Valley networks provide compelling evidence that past geologic processes on Mars were different than those seen today. The generally accepted paradigm is that these features formed from groundwater circulation, which may have been driven by differential heating induced by magmatic intrusions, impact melt, or a higher primordial heat flux. Although such mechanisms may not require climatic co...

Quantum consciousness in warm, wet, and noisy brain

The emergence of quantum consciousness stems from dynamic flows of hydrogen ions in brain liquid. This liquid contains vast areas of the fourth phase of water with hexagonal packing of its molecules, the so-called exclusion zone (EZ) of water. The hydrogen ion motion on such hexagonal lattices shows as the hopping of the ions forward and the holes (vacant places) backward, caused by the Grotthu...